منابع مشابه
Mitochondrial deafness alleles confer misreading of the genetic code.
Despite the fact that important genetic diseases are caused by mutant mitochondrial ribosomes, the molecular mechanisms by which such ribosomes result in a clinical phenotype remain largely unknown. The absence of experimental models for mitochondrial diseases has also prevented the rational search for therapeutic interventions. Here, we report on the construction of bacterial hybrid ribosomes ...
متن کاملA structural basis for streptomycin-induced misreading of the genetic code
During protein synthesis, the ribosome selects aminoacyl-transfer RNAs with anticodons matching the messenger RNA codon present in the A site of the small ribosomal subunit. The aminoglycoside antibiotic streptomycin disrupts decoding by binding close to the site of codon recognition. Here we use X-ray crystallography to define the impact of streptomycin on the decoding site of the Thermus ther...
متن کاملOn Misreading the Linguistic Analogy : Response to
Oscar Wilde noted " Always forgive your enemies-nothing annoys them so much. " Before we forgive our critics, however, we thank Prinz and Mallon for their thoughtful comments, and for taking the linguistic analogy as a serious proposal amidst the current excitement at the interface between moral philosophy and moral psychology. What we forgive is their targeted comments on several issues that a...
متن کاملMisreading of the tuberculin skin test.
this hypothesis would need to be tested in a prospective trial. How long had nifedipine been discontinued in the authors' patient prior to repeat cardiac catheterization? How long has the patient's exercise tolerance remained dramatically improved since the discontinuation of vasodilators?
متن کاملMolecular misreading: the occurrence of frameshift proteins in different diseases.
Neuronal homoeostasis requires a constant balance between biosynthetic and catabolic processes. Eukaryotic cells primarily use two distinct mechanisms for degradation: the proteasome and autophagy of aggregates by the lysosomes. We focused on the UPS (ubiquitin-proteasome system). As a result of molecular misreading, misframed UBB (ubiquitin B) (UBB+1) is generated. UBB+1 accumulates in the neu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2009
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc2679